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Nitrated nucleosome levels and neuropsychiatric events in systemic lupus erythematosus; a multi-center retrospective case-control study

Ferreira, Isabel (author)
University College London
Croca, Sara (author)
University College London
Raimondo, Maria Gabriella (author)
University College London
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Matharu, Manjit (author)
University College London
Miller, Sarah (author)
University College London
Giles, Ian (author)
University College London
Isenberg, David (author)
University College London
Ioannou, Yiannis (author)
University College London
Hanly, John G. (author)
Dalhousie University
Urowitz, Murray B. (author)
University of Toronto
Anderson, Nicole (author)
University of Toronto
Aranow, Cynthia (author)
Feinstein Institute for Medical Research
Askanase, Anca (author)
Columbia University
Bae, Sang Cheol (author)
Hanyang University
Bernatsky, Sasha (author)
McGill University Health Center
Bruce, Ian N. (author)
University of Manchester
Buyon, Jill (author)
Clarke, Ann E. (author)
University of Calgary
Dooley, Mary Anne (author)
University of North Carolina
Fortin, Paul (author)
Centre Hospitalier de l'Universite Laval (CHUL)
Ginzler, Ellen (author)
Gladman, Dafna (author)
University of Toronto
Gordon, Caroline (author)
University of Birmingham
Inanc, Murat (author)
Istanbul University
Jacobsen, Søren (author)
Copenhagen University Hospital
Kalunian, Kenneth (author)
Kamen, Diane (author)
Khamashta, Munther (author)
King's College London
Lim, Sam (author)
Emory University
Manzi, Susan (author)
Merrill, Joan (author)
Oklahoma Medical Research Foundation
Nived, Ola (author)
Lund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine
Peschken, Christine (author)
University of Manitoba
Petri, Michelle (author)
Johns Hopkins University School of Medicine
Ramsey-Goldman, Rosalind (author)
Northwestern University Feinberg School of Medicine
Ruiz-Irastorza, Guillermo (author)
University of the Basque Country
Sanchez-Guerrero, Jorge (author)
University of Toronto
Steinson, Kristjan (author)
National University Hospital of Iceland
Sturfelt, Gunnar K. (author)
Lund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine
van Vollenhoven, Ronald (author)
Karolinska Institutet
Wallace, Daniel J. (author)
Jonsson Comprehensive Cancer Center
Zoma, Asad (author)
Hairmyres Hospital
Rahman, Anisur (author)
University College London
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 (creator_code:org_t)
2017-12-22
2017
English.
In: Arthritis Research and Therapy. - : Springer Science and Business Media LLC. - 1478-6354 .- 1478-6362. ; 19:1
Related links:
http://dx.doi.org/10... (free)
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https://arthritis-re...
https://lup.lub.lu.s...
https://doi.org/10.1...
http://kipublication...
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  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Background: In patients with systemic lupus erythematosus (SLE) there is no serological test that will reliably distinguish neuropsychiatric (NP) events due to active SLE from those due to other causes. Previously we showed that serum levels of nitrated nucleosomes (NN) were elevated in a small number of patients with NPSLE. Here we measured serum NN in samples from a larger population of patients with SLE and NP events to see whether elevated serum NN could be a marker for NPSLE. Methods: We obtained serum samples from patients in the Systemic Lupus International Collaborative Clinics (SLICC) inception cohort. This included 216 patients with NP events and two matched controls with SLE but no NP events for each of these patients. For the NP patients we tested samples taken before, during and after the NP event. Results: Twenty-six patients had events attributed to SLE according to the most stringent SLICC attribution rule. In these patients there was no association between onset of event and elevated serum NN. In 190 patients in whom events were not attributed to SLE by the SLICC rules, median serum NN was elevated at the onset of event (P = 0.006). The predominant clinical features in this group of 190 patients were headache, mood disorders and anxiety. Conclusions: Serum NN levels rise at the time of an NP event in a proportion of patients with SLE. Further studies are needed to determine the value of serum NN as a biomarker for NPSLE.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)

Keyword

Neuropsychiatric
Nitration
Nucleosomes
Systemic lupus erythematosus

Publication and Content Type

art (subject category)
ref (subject category)

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